What is the primary immune response of the skin?

The primary immune response of the skin involves the activation of Langerhans cells. These specialized dendritic cells are found within the epidermis and play a crucial role in the skin's immune defense. When the skin is exposed to pathogens, Langerhans cells can detect these intruders and capture antigens. After this, they migrate to the nearest lymph nodes to present the processed antigens to T cells, initiating an adaptive immune response.

This activation is essential in forming a protective response against infections, particularly for the first line of defense the skin provides. The role of Langerhans cells illustrates how the skin is not just a physical barrier but also an active participant in immune surveillance, detecting and responding to potential threats.